AmoyDx® ROS1 Gene Fusions Detection Kit | 8.01.23201W012

AmoyDx® ROS1 Gene Fusions Detection Kit | 8.01.23201W012 | Gentaur UK, US & Europe Distribution  

ROS1 is a receptor tyrosine kinase of insulin receptor family. ROS1 gene fusions define a unique molecular subset of non-small-cell lung cancer (NSCLC). The ROS1 fusion partners include SLC34A2, CD74, SDC4, EZR etc. These fusions lead to constitutive kinase activity and activation of downstream pathways, such as JAK/STAT, PI3K/AKT, RAS/MAPK etc., leading to carcinogenesis. It has been reported that the presence of the ROS1 rearrangement is correlated with the efficacy of TKI therapy.

Based on analysis of tumor messenger RNA, ROS1 gene fusions can be detected by real-time PCR method.

Intended Use

The AmoyDx® ROS1 Gene Fusions Detection Kit is a real-time PCR assay for qualitative detection of 14 ROS1 gene fusions in human total RNA extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissues in NSCLC patients. The kit is intended to assess ROS1 gene status in NSCLC patients and to aid the clinician in identifying NSCLC patients who may response to ROS1 inhibitor therapy.

The kit is for in vitro diagnostic use, and intended to be used by trained professionals in a laboratory environment.