AMPK alpha2 Polyclonal Antibody | E-AB-40256

AMPK alpha2 Polyclonal Antibody | E-AB-40256 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 5'-AMP-activated protein kinase catalytic subunit alpha-2, AAPK2, ACACA kinase, Acetyl-CoA carboxylase kinase, AMPK alpha 2 chain, AMPK subunit alpha-2, AMPK2, AMPKa2, AMPKalpha2, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, PRKAA, PRKAA2, Protein kinase AMP activated alpha 2 catalytic subunit, Protein kinase AMP activated catalytic subunit alpha 2

Application: WB, IHC, IF

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Rat 5'-AMP-activated protein kinase catalytic subunit alpha-2 protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Antigen Affinity Purification

Dilution: WB 1:500-1:2000 IHC 1:100-1:200 IF 1:100-1:400

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 62, 4 kDa

Molecular Weight(Observed): 62 kDa