Amsacrine | B2445

Amsacrine is a potent DNA intercalating and an antineoplastic agent. One of the ways amsacrine works is by blocking an enzyme topoisomerase 2. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols.

Amsacrine is a potent DNA intercalating and an antineoplastic agent. One of the ways amsacrine works is by blocking an enzyme topoisomerase 2. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols.

B2445 | Amsacrine DataSheet

Alternate Name/Synonyms: Amsidine, N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide, m-AMSA

Appearance: Crystalline solid

Formulation:

CAS Number: 51264-14-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₉N₃O₃S

Molecular Weight: 393.46

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >8 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A topoisomerase II inhibitor

MDL Number:

PubChem CID: 2179

SMILES: COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42

InChi: InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23)

InChi Key: XCPGHVQEEXUHNC-UHFFFAOYSA-N