Anagrelide | B2446

Anagrelide is a phosphodiesterase 3 (PDE3) inhibitor (IC₅₀ = 36 nM) with antiplatelet activity. Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. Anagrelide is used for the treatment of overproduction of blood platelets.

Anagrelide is a phosphodiesterase 3 (PDE3) inhibitor (IC₅₀ = 36 nM) with antiplatelet activity. Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. Anagrelide is used for the treatment of overproduction of blood platelets.

B2446 | Anagrelide DataSheet

Alternate Name/Synonyms: Agrelin, Thromboreductin, 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one, BL 4162A

Appearance: Crystalline solid

Formulation:

CAS Number: 68475-42-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₇Cl₂N₃O

Molecular Weight: 256.09

Cell-Permeable?: True

Purity: ≥98%

Solubilities: DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A phosphodiesterase 3 (PDE3) Inhibitor

MDL Number:

PubChem CID: 135409400

SMILES: C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3

InChi: InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)

InChi Key: OTBXOEAOVRKTNQ-UHFFFAOYSA-N