ANKH polyclonal Antibody | BS71362

ANKH polyclonal Antibody | BS71362 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: ANKH (progressive ankylosis protein homolog) is a multi-pass transmembrane protein involved in bone mineralization and joint maintenance. ANKH is a ubiquitously expressed protein with high expression levels in the embryonic developing articular cartilage of joints in the elbow, wrist, shoulders and digits. Expression of ANKH is regulated by cytokines and various growth factors. ANKH functions as a transporter, regulating the extracellular transport of inorganic pyrophosphates (PPi) . The extracellular level of inorganic pyrophosphates can both inhibit and promote different types of pathologic mineralization. Mutations in ANKH are associated with various human skeletal defects including calcium pyrophosphate deposition disease (CPPD) and craniometaphyseal dysplasia Jackson type (CMDJ) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ANKH polyclonal Antibody detects endogenous levels of ANKH protein.

Molecular Weight: ~ 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Progressive ankylosis protein homolog; ANK; KIAA1581; UNQ241/PRO274

Immunogen: Recombinant protein of human ANKH.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: