Anti-11-Dehydro TXB2 Antibody | A2165

Thromboxane A2 (TxA2) is a prostaglandin metabolite that is metabolically derived from arachidonic acid (AA) via the action of cyclooxygenases (COX1 in platelets and COX2 in monocytes and endothelial cells). TxA2 is a vasoactive agent that regulates blood flow and blood pressure. Additionally, it acts as a pro-thrombotic agent that promotes the activation and aggregation of platelets. However, TxA2 is highly unstable with a short half-life (20-30 secs). It is readily converted to a stable metabolite thromboxane B2, which further undergoes dehydrogenation to form 11-dehydro thromboxane B2 (11dhTxB2). 11dhTxB2 is excreted in urine and has a longer half-life than TxA2. The metabolite is unaffected by the ex vivo platelet activation and other pre-analytical variables and hence is a valid biomarker to determine platelet activity. 11dhTxB2 is found to be elevated in multiple atherothrombotic diseases. Additionally, an elevated level of 11dhTxB2 in urine indicates aspirin resistance in patients receiving antiplatelet aspirin therapy.

A2165 | Anti-11-Dehydro TXB2 Antibody DataSheet

Antibody Target: 11-Dehydro TXB2

Target Alternative Name: 11-Dehydro-thromboxane B2, 11-Dehydro-txb2, 11-dehydrothromboxane B2, 11-Keto-thromboxane B2, 11dhTxB2 antibody

Tag Line: Recombinant mouse monoclonal antibody to detect 11-dehydro Thromboxane B2 expression in human urine samples

Category: Primary antibody

Host: Recombinant

Isotype: IgG1

Species Reactivities:

Immunogen Sequence:

Accession #:

Gene ID:

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In 500 mM Diethanolamine, 1.0 M NaCl, 10 mM EDTA, 1% BSA, pH 8.7

Purification: Protein A purified

Application: ELISA

Positive Control:

Application And Usages: ELISA

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: TRUE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE