Anti-ACLY (ATP citrate lyase) monoclonal Antibody | MB62159

Anti-ACLY (ATP citrate lyase) monoclonal Antibody | MB62159 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, IHC, WB

Application Range: WB 1:2000, IHC 1:50, IF 1:100

Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: ATP citrate lyase

Molecular Weight: 120.8 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ACL; ATPCL; CLATP

Immunogen: Full length human recombinant protein of human ACLY (NP_001087) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A