Anti- ALK, CD246 Antibody | FNab00310

Anti- ALK, CD246 Antibody | FNab00310 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 2B10

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin) -ALK oncogenic fusion protein, resulting from the (2;5) (p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL) . The EML4 (echinoderm microtubule-associated protein-like 4) -ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570) .

Immunogen: anaplastic lymphoma receptor tyrosine kinase

synonyms: ALK, ALK tyrosine kinase receptor, ALK, CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK

Molecular weight (observed) : 176 kDa

Reactivity Species: Human

Tested Application: ELISA, IHC, WB

Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200

Research Area: Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience