Anti- ALKBH5 Antibody | FNab00314

Anti- ALKBH5 Antibody | FNab00314 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N (6) -methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Can also demethylate N (6) -methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105) . Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736) . Required for spermatogenesis (By similarity) .

Immunogen: alkB, alkylation repair homolog 5 (E. coli)

synonyms: ABH5, ALKBH5, FLJ20308, OFOXD, OFOXD1

Molecular weight (observed) : 51 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IF

Recomended Dillution : WB: 1:200-1:1000

Research Area: Metabolism