Anti-ALOX5 Antibody | A1747

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

A1747 | Anti-ALOX5 Antibody DataSheet

Antibody Target: Arachidonate 5-lipoxygenase

Target Alternative Name: 5 LOX, 5-lipoxygenase, Arachidonate 5 lipoxygenase, arachidonic 5-lipoxygenase delta-10-13 isoform, Leukotriene A4 synthase, mgC163204

Tag Line: Polyclonal antibody to detect Anti-ALOX5 Antibody in human, mouse and rat samples.

Category: Signal Transduction

Host: Rabbit

Isotype: IgG

Species Reactivities: Rat, Mouse, Human

Immunogen Sequence: Recombinant protein of human ALOX5

Accession #: P09917

Gene ID: 240

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.7 mg/ml

Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3

Purification: Affinity purification

Application: Immunohistochemistry (IHC), ELISA

Positive Control:

Application And Usages: IHC 1:50-1:150

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: True

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False