Anti- AMACR/p504S Antibody | FNab00355

Anti- AMACR/p504S Antibody | FNab00355 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: AMACR (Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa) . However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR (PMID:12213712) . It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa (PMID:21812041) . Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4) .

Immunogen: alpha-methylacyl-CoA racemase

synonyms: 2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE

Molecular weight (observed) : 42 kDa

Reactivity Species: Human, rat

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:5000; IHC: 1:20-1:200

Research Area: Stem Cells, Immunology, Metabolism, Cancer