710

Anti- APTX Antibody | FNab10359

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SKU:
710-FNab10359-GEN
Availability:
In Stock - Delivery within a week
NULL371.00

Description

Anti- APTX Antibody | FNab10359 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: APTX, also named as Aprataxin, is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. APTX is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. APTX contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes.

Immunogen: aprataxin

synonyms: AOA, AOA1, aprataxin, APTX, AXA1, EAOH, EOAHA, FHA HIT

Molecular weight (observed) : 40 kDa

Reactivity Species: Human

Tested Application: ELISA, IHC

Recomended Dillution : WB: 1:500 - 1:2000; IHC: 1:20 - 1:200

Research Area: N/A

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Additional Information

Size:
100 µg
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