Anti- ATF6 Antibody | FNab00664

Anti- ATF6 Antibody | FNab00664 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N (9) -CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') . Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Immunogen: activating transcription factor 6

synonyms: ATF6, ATF6 alpha, ATF6A

Molecular weight (observed) : 90 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB, IF

Recomended Dillution : WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Research Area: Signal Transduction, Metabolism