Anti- ATF6B Antibody | FNab00665

Anti- ATF6B Antibody | FNab00665 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: The endoplasmic reticulum (ER) -transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR) . The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms (60, 80kd ) (PMID: 11256944)

Immunogen: activating transcription factor 6 beta

synonyms: CREBL1, G13

Molecular weight (observed) : 110 kDa, 60 kDa, 80 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC, IP

Recomended Dillution : WB: 1:1000-1:4000; IP:1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Research Area: Signal Transduction, Metabolism