Anti- ATX3, ATXN3 Antibody | FNab00739

Anti- ATX3, ATXN3 Antibody | FNab00739 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.

Immunogen: ataxin 3

synonyms: AT3, ataxin 3, ATX3, ATXN3, JOS, MJD, MJD1, SCA3

Molecular weight (observed) : 38 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recomended Dillution : WB: 1:500-1:1000; IHC: 1:20-1:200

Research Area: Neuroscience, Metabolism, Developmental biology