Anti- BARD1 Antibody | FNab00803

Anti- BARD1 Antibody | FNab00803 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

Immunogen: BRCA1 associated RING domain 1

synonyms: BARD 1, BARD1, BRCA1 associated RING domain 1

Molecular weight (observed) : 90-100 kDa

Reactivity Species: Human

Tested Application: ELISA, IHC, IF, IP, FC, WB

Recomended Dillution : WB: 1:500-1:1000

Research Area: Epigenetics, Metabolism