Anti- BAX Antibody | FNab00810

Anti- BAX Antibody | FNab00810 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035) . BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611) . The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579) .

Immunogen: BCL2-associated X protein

synonyms: BCL2L4, Apoptosis regulator BAX, BAX

Molecular weight (observed) : 21 kDa

Reactivity Species: Human, Mouse, Rat, Rabbit, Sheep

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200

Research Area: Neuroscience, Cancer, Developmental biology