Anti- BCL2 Antibody | FNab00840

Anti- BCL2 Antibody | FNab00840 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 8A10

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .

Immunogen: B-cell CLL/lymphoma 2

synonyms: Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, Oncogene B cell leukemia 2

Molecular weight (observed) : 26 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000

Research Area: Neuroscience, Cancer, Immunology, Cardiovascular