Anti- BCL2L1 Antibody | FNab00843

Anti- BCL2L1 Antibody | FNab00843 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 2A9

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X (L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F (1) F (0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) . Isoform Bcl-X (S) promotes apoptosis.

Immunogen: BCL2-like 1

synonyms: BCL2L, BCLX

Molecular weight (observed) : 35 kDa

Reactivity Species: Human

Tested Application: ELISA, IHC, IP, IF, WB

Recomended Dillution : WB: 1:2000-1:20000; IHC: 1:200-1:600; IF: 1:10-1:100

Research Area: Neuroscience, Cancer, Immunology, Cardiovascular