Anti-BRAF monoclonal Antibody | MB62189

Anti-BRAF monoclonal Antibody | MB62189 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: FC, IF, IP, WB

Application Range: WB 1:2000, IF 1:100, Flow 1:100

Background: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: B-Raf proto-oncogene, serine/threonine kinase

Molecular Weight: 84.4 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: B-raf; B-RAF1; BRAF1; NS7; RAFB1

Immunogen: Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A