Anti- CEBPB Antibody | FNab01580

Anti- CEBPB Antibody | FNab01580 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749) . Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity) . During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347) . Essential for female reproduction because of a critical role in ovarian follicle development (By similarity) . Restricts osteoclastogenesis (By similarity) . Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4 (+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938) . Promotes osteoblast differentiation and osteoclastogenesis (By similarity) .

Immunogen: CCAAT/enhancer binding protein (C/EBP), beta

synonyms: TCF5

Molecular weight (observed) : 36 kDa

Reactivity Species: Human, Rat

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:2000

Research Area: Epigenetics, Cardiovascular, Metabolism, Developmental biology