Anti- COPS8 Antibody | FNab01874

Anti- COPS8 Antibody | FNab01874 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Immunogen: COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

synonyms: COP9, COP9 homolog, COPS8, CSN8, hCOP9, SGN8, Signalosome subunit 8

Molecular weight (observed) : 23 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recomended Dillution : WB: 1:200-1:2000; IHC: 1:20-1:200

Research Area: stem cells, immunology, Developmental biology, Signal Transduction, Cell Division and Proliferation