Anti-ERBB3 Polyclonal Antibody | A1863

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

A1863 | Anti-ERBB3 Polyclonal Antibody DataSheet

Antibody Target: ERBB3

Target Alternative Name: ErbB-3, ERBB3, c-erbB-3, MDA-BF-1, c-erbB3, erbB3-S, HER3, p85-sErbB3, p45-sErbB3, erb-b2 receptor tyrosine kinase 3, p180-ErbB3, LCCS2

Tag Line: Affinity purified Rabbit polyclonal to ERBB3

Category: Primary antibody

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Rat, Mouse, Human

Immunogen Sequence: Recombinant fusion protein containing a sequence corresponding to amino acids 20-285 of human ERBB3 (NP_001973.2).

Accession #: P21860

Gene ID: 2065

Appearance: Liquid

Form: Liquid

Concentration:

Formulation: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification: Affinity purification

Application: Western Blotting

Positive Control:

Application And Usages: WB 1:500 - 1:2000

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: False

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False