Anti-ERCC1 Antibody | A1937

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

A1937 | Anti-ERCC1 Antibody DataSheet

Antibody Target: ERCC1

Target Alternative Name: ERCC1; COFS4; RAD10; UV20; DNA excision repair protein ERCC-1

Tag Line: Affinity purified rabbit polyclonal antibody to ERCC1

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Mouse, Human

Immunogen Sequence: Recombinant fusion protein corresponding to aa 1-323 of human ERCC1 (NP_973730.1)

Accession #: P07992

Gene ID: 2067

Appearance: Liquid

Form: Liquid

Concentration:

Formulation: In PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purified

Application: Immunofluorescence (IF), Western Blotting

Positive Control:

Application And Usages: IF 1:50 - 1:200, WB 1:500 - 1:2000

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: False

Immunofluorescence Verified: True

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False