Anti-ERCC1 monoclonal Antibody | MB62238

Anti-ERCC1 monoclonal Antibody | MB62238 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Monkey, Mouse, Dog

Application: FC, IF, WB

Application Range: WB 1:500~2000, IF 1:100, FLOW 1:100

Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: ERCC excision repair 1, endonuclease non-catalytic subunit

Molecular Weight: 32.4 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: COFS4; RAD10; UV20

Immunogen: Full length human recombinant protein of human ERCC1 (NP_973730) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A