Anti- ERCC6 Antibody | FNab02836

Anti- ERCC6 Antibody | FNab02836 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX (ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.

Immunogen: excision repair cross-complementing rodent repair deficiency, complementation group 6

synonyms: CSB

Molecular weight (observed) : 150kd

Reactivity Species: Human

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:2000

Research Area: Epigenetics, Metabolism