Anti- GLRA1 Antibody | FNab03486

Anti- GLRA1 Antibody | FNab03486 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860) . Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272) . Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272) . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753) . Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) . Channel activity is potentiated by ethanol (PubMed:25973519) . Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity) .

Immunogen: glycine receptor, alpha 1

synonyms: N/A

Molecular weight (observed) : 48 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:500-1:2000

Research Area: Neuroscience, Signal Transduction, Developmental biology