Anti- HELB Antibody | FNab03821

Anti- HELB Antibody | FNab03821 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285) . Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285) . As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285) . Acts independently of TP53BP1 (PubMed:26774285) . Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327) . During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613) .

Immunogen: helicase (DNA) B

synonyms: N/A

Molecular weight (observed) : 120-140 kDa

Reactivity Species: Human

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:2000; IF: 1:20-1:200

Research Area: Metabolism