Anti-HER2/ErbB2 Antibody | A2212

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand-binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

A2212 | Anti-HER2/ErbB2 Antibody DataSheet

Antibody Target: HER2/ErbB2

Target Alternative Name: HER2, MLN19, NEU, NGL, TKR1, HER-2, HER-2/neu, p185erbB2, CD340, EC 2.7.10.1, MLN 19, C-Erb B2/Neu Protein, CD340 Antigen, HER-2/Neu, Herstatin, EC 2.7.10, ERBB2, MLN19, TKR

Tag Line: Rabbit polyclonal antibody to detect HER2 expression in human, mouse, rat and dog samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Dog,Rat,Mouse,Human

Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the center region of human HER2

Accession #: P04626

Gene ID: 2064

Appearance: Colorless liquid

Form: Liquid

Concentration: 1 mg/ml

Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide

Purification: Affinity purified

Application: Immunohistochemistry (IHC),Immunofluorescence (IF),Western Blotting

Positive Control:

Application And Usages: WB (1:500 – 1:1000), IHC (1:100 – 1:200), IF (1:100 – 1:500)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: TRUE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE