Anti-Human CD196/CCR6 Monoclonal Antibody (FITC Conjugated) | DL21844F

Anti-Human CD196/CCR6 Monoclonal Antibody (FITC Conjugated) | DL21844F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: CKRL3, CMKBR6, GPR29, STRL22, GPRCY4

Reactivity: Human

Application: FCM

Background: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs) . CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Concentration: N/A

Conjugation: FITC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: G034E3

Isotype: Mouse IgG2b, κ