Anti-Human CD49d Monoclonal Antibody (Biotin Conjugated) | DL20593F

Anti-Human CD49d Monoclonal Antibody (Biotin Conjugated) | DL20593F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Integrin alpha-4, ITGA4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha, CD49d

Reactivity: Human

Application: FCM

Background: CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7) . CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

Concentration: 0.5 mg/mL

Conjugation: Biotin

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: BU49

Isotype: Mouse IgG1, κ