Anti-Human IL-17A Monoclonal Antibody (APC Conjugated) | DL21925F

Anti-Human IL-17A Monoclonal Antibody (APC Conjugated) | DL21925F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: CTLA8, IL17, CTLA-8, IL 17A

Reactivity: Human

Application: ICFCM

Background: IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA) . Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.

Concentration: N/A

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: BL168

Isotype: Mouse IgG1, κ