Anti-Human IL-21 Monoclonal Antibody (APC Conjugated) | DL22177F

Anti-Human IL-21 Monoclonal Antibody (APC Conjugated) | DL22177F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Interleukin-21, IL-21, Za11

Reactivity: Human

Application: ICFCM

Background: Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

Concentration: N/A

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: 3A3-N2

Isotype: Mouse IgG1, κ