Anti-ICOSL Antibody (Clone# ICOSL/3111) | A2274

ICOSL (also known as B7-H2, CD275) is a cell surface antigen that belongs to the family of B7 proteins. It is constitutively expressed by antigen-presenting cells (APCs) such as B cells, dendritic cells, and activated monocytes. It is also the ligand for ICOS, a cell-surface receptor that is expressed by activated T cells. Binding of ICOSL to ICOS leads to activation and proliferation of T cells, as well as the survival of memory T cells. ICOSL plays an important role in diseases such as rheumatoid arthritis, systemic lupus erythematosus, and uveitis, where it triggers the release of cytokines such as IL-10, IL-4, and IFN-?. ICOSL expression has been observed in several cancers; however, its role is not yet determined.

A2274 | Anti-ICOSL Antibody (Clone# ICOSL/3111) DataSheet

Antibody Target: ICOSL

Target Alternative Name: B7h, B7H2, GL50, B7-H2, B7RP1, CD275, ICOSL, LICOS, B7RP-1, ICOS-L, ICOSLG

Tag Line: Mouse monoclonal antibody to detect the expression of ICOSL in human samples

Category: Primary antibody

Host: Mouse

Isotype: IgG1, kappa

Species Reactivities: Human

Immunogen Sequence: Recombinant fragment of human ICOSL protein (aa 23-149)

Accession #: O75144

Gene ID: 23308

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In 10 mM PBS

Purification: Protein A/G purified

Application: Immunohistochemistry (IHC) Immunofluorescence (IF) Flow Cytometry

Positive Control:

Application And Usages: FC (1-2 µg/million cells), IF (1-2 µg/ml), IHC (1-2 µg/ml)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE