Anti-IFT57 (HIPPI) monoclonal Antibody | MB62280

Anti-IFT57 (HIPPI) monoclonal Antibody | MB62280 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, IHC, WB

Application Range: WB 1:2000, IHC 1:50, IF 1:100

Background: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1,leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: intraflagellar transport 57

Molecular Weight: 49.1 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ESRRBL1; HIPPI; MHS4R2

Immunogen: Full length human recombinant protein of human IFT57 (NP_060480) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A