710
Anti- LATS1 Antibody | FNab04708
- SKU:
- 710-FNab04708-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- LATS1 Antibody | FNab04708 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Immunogen: LATS, large tumor suppressor, homolog 1
synonyms: LATS1, WARTS, WARTS protein kinase, wts
Molecular weight (observed) : 140 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC
Recomended Dillution : WB: 1:200-1:1000; IHC: 1:20-1:200
Research Area: Signal Transduction, Metabolism