Anti- liver Arginase Antibody | FNab04801

Anti- liver Arginase Antibody | FNab04801 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 4A0

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation (PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins (PMID: 20071539) .It can exsit as a homotrimer (PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia (ARGIN) . Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control. (PMID:27117406) .

Immunogen: arginase, liver

synonyms: ARG1, Arginase 1, liver Arginase, Liver type arginase

Molecular weight (observed) : 35 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, IHC, IP, IF, FC, WB

Recomended Dillution : WB: 1:1000-1:8000; IHC: 1:200-1:1000

Research Area: Signal Transduction, Metabolism