Anti-Mouse CD103 Monoclonal Antibody (AF647 Conjugated) | DL21018F

Anti-Mouse CD103 Monoclonal Antibody (AF647 Conjugated) | DL21018F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: Integrin alpha-E, Itgae, Integrin alpha M290, CD103

Reactivity: Mouse

Application: FCM

Background: CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL) . CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Concentration: N/A

Conjugation: AF647

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: M290

Isotype: Rat IgG2a, κ