Anti-Mouse CD274/PD-L1 Monoclonal Antibody (APC Conjugated) | DL21661F

Anti-Mouse CD274/PD-L1 Monoclonal Antibody (APC Conjugated) | DL21661F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1

Reactivity: Mouse

Application: FCM

Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Concentration: 0.2 mg/mL

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: 10F.9G2

Isotype: Rat IgG2b, κ