Anti-Mouse CD279/PD-1 Monoclonal Antibody (AF647 Conjugated) | DL21646F

Anti-Mouse CD279/PD-1 Monoclonal Antibody (AF647 Conjugated) | DL21646F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: PD-1, Programmed Death-1

Reactivity: Mouse

Application: FCM

Background: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Concentration: N/A

Conjugation: AF647

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: 29F.1A12

Isotype: Rat IgG2a, κ