Anti-Mouse CD40 Monoclonal Antibody (AF488 Conjugated) | DL20456F

Anti-Mouse CD40 Monoclonal Antibody (AF488 Conjugated) | DL20456F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: Tumor necrosis factor receptor superfamily member 5, Cd40, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, Tnfrsf5

Reactivity: Mouse

Application: FCM

Background: CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

Concentration: 0.5 mg/mL

Conjugation: AF488

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: FGK4.5/FGK45

Isotype: Rat IgG2a, κ