Anti-Mouse/Human CD44 Monoclonal Antibody (Biotin Conjugated) | DL21177F

Anti-Mouse/Human CD44 Monoclonal Antibody (Biotin Conjugated) | DL21177F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: CD44 antigen, CD44, CDw44, Epican, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, LHR, MDU2, MDU3, MIC4

Reactivity: Human, Mouse

Application: FCM

Background: CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Concentration: 0.5 mg/mL

Conjugation: Biotin

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: IM7

Isotype: Rat IgG2b, κ