Anti- NCAM1/CD56 Antibody | FNab05575

Anti- NCAM1/CD56 Antibody | FNab05575 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 0D10

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812) . The glycosylphosphatidylinositol (GPI) -anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII) . All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519) . Several other isofroms have also been described (PMID: 1856291) .

Immunogen: neural cell adhesion molecule 1

synonyms: CD56, MSK39, N CAM 1, NCAM, NCAM 1, NCAM1

Molecular weight (observed) : 140 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:1000-1:10000; IHC: 1:200-1:1000

Research Area: Signal Transduction, Immunology, Cancer, Developmental biology, Neuroscience, Stem Cells