710
Anti- NDFIP1 Antibody | FNab05602
- SKU:
- 710-FNab05602-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- NDFIP1 Antibody | FNab05602 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity) . In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (PubMed:19706893) . Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535) . Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046) .
Immunogen: Nedd4 family interacting protein 1
synonyms: N4WBP5
Molecular weight (observed) : 30 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IP
Recomended Dillution : WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Research Area: Epigenetics, Signal Transduction