Anti- NOTCH3 Antibody | FNab05800

Anti- NOTCH3 Antibody | FNab05800 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) .

Immunogen: Notch homolog 3

synonyms: CADASIL, CASIL, Notch 3, Notch homolog 3, NOTCH3

Molecular weight (observed) : 250-260 kDa, 100 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recomended Dillution : WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500

Research Area: Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology