Anti- NRF2, NFE2L2 Antibody | FNab05855

Anti- NRF2, NFE2L2 Antibody | FNab05855 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress (PMID:14567983) .In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance (PMID:20534738) . Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.

Immunogen: nuclear factor (erythroid-derived 2) -like 2

synonyms: HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2

Molecular weight (observed) : 70-100 kDa

Reactivity Species: Human, Mouse, Rat, Zebrafish

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500

Research Area: Epigenetics, Cancer, Metabolism, Developmental biology