Anti-PAD2 Polyclonal Antibody | A2322

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD2 is the most widely expressed and evolutionarily conserved family member. Known substrates for PAD2 include myelin basic protein and vimentin, and PAD2 is thought to play a role in the onset and progression of neurodegenerative diseases such as Alzheimer's and multiple sclerosis. PAD2 may also play a role in transcriptional regulation as it is capable of citrullinating histone H3.

A2322 | Anti-PAD2 Polyclonal Antibody DataSheet

Antibody Target:

Target Alternative Name: Peptidyl Arginine Deiminase 2; PDI2; Protein-Arginine Deiminase Type II; EC 3.5.3.15; KIAA0994; PAD-H19; PADI2

Tag Line: Potentially involved in autoimmune diseases

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human

Immunogen Sequence: Recombinant Human PAD2 protein (amino acids 1 to 665)

Accession #: Q9Y2J8

Gene ID: 11240

Appearance:

Form: Rabbit polyclonal

Concentration:

Formulation: 0.01 M PBS, pH 7.4 with 50% glycerol, 0.03% Proclin 300

Purification: Protein G purification

Application: Immunofluorescence (IF) Immunohistochemistry (IHC) Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: TRUE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: TRUE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE