Anti-PAD4 Monoclonal Antibody (Clone 11F9) | A2314

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.

A2314 | Anti-PAD4 Monoclonal Antibody (Clone 11F9) DataSheet

Antibody Target: Human PAD4

Target Alternative Name: Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4

Tag Line: Protein arginine deiminase associated with rheumatoid arthritis

Category: GM-CSF

Host: Mouse

Isotype: Mouse IgG1

Species Reactivities: Human

Immunogen Sequence: Full length recombinant PAD4 protein

Accession #: Q9UM07

Gene ID: 23569

Appearance: Liquid

Form: Mouse monoclonal

Concentration:

Formulation: In PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide

Purification: Protein G purification

Application: Western Blotting ELISA

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE