Anti- PARN Antibody | FNab06150

Anti- PARN Antibody | FNab06150 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly (A) as the substrate, hence, efficiently degrades poly (A) tails of mRNAs. Exonucleolytic degradation of the poly (A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen: poly (A) -specific ribonuclease (deadenylation nuclease)

synonyms: DAN

Molecular weight (observed) : 90 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IF

Recomended Dillution : WB: 1:1000 - 1:3000; IHC: 1:50 - 1:200

Research Area: Metabolism