Anti- PDE9A Antibody | FNab06263

Anti- PDE9A Antibody | FNab06263 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814) . Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991) . Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable) . In brain, involved in cognitive function, such as learning and long-term memory (By similarity) .

Immunogen: phosphodiesterase 9A

synonyms: HSPDE9A2, PDE9A, phosphodiesterase 9A

Molecular weight (observed) : N/A

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recomended Dillution : IHC: 1:100-1:200; IF: 1:50-1:500

Research Area: Signal Transduction, Metabolism